Genetics/Genomics News

Researchers have discovered genetic evidence that some of the risk for non-syndromic congenital heart disease is inherited from healthy parents.

The TAILOR-PCI study has received an additional $7 million from the National Heart, Lung and Blood Institute to complete research on whether prescribing antiplatelet therapy based on a patient’s CYP2C19 genotype will prevent MI, stroke, unstable angina and CV death in patients who undergo PCI.

An atrial fibrillation–associated single nucleotide polymorphism, rs10824026, may partially be the cause of the paradoxical racial difference in risk for atrial fibrillation between white and black individuals, researchers reported in JAMA Cardiology.

Adding genetic risk score to phenotypic risk prediction of CVD added minimum benefit overall, but it may improve predictability in those at intermediate risk, according to data published in Heart.

CHD onset in patients with high cholesterol levels caused by heterozygous familial hypercholesterolemia can be accelerated by decades, according to study data published in Circulation.

In a subgroup analysis of the CHANCE trial, clopidogrel plus aspirin was only effective in reducing the risk for new stroke after minor stroke or transient ischemic attack in patients who were not carriers of CYP2C19 loss-of-function alleles.

The addition of genetic testing to the autopsy investigation may better identify possible causes of sudden cardiac death in children and young adults, according to data published in The New England Journal of Medicine.

Athletes with catecholaminergic polymorphic ventricular tachycardia, or CPVT, may safely compete if shared decision making and effective treatment are utilized, according to data published in JACC: Clinical Electrophysiology.

A common genetic variant is associated with increased risk for acute kidney injury after cardiac surgery, recent findings indicate.

Researchers reported in The New England Journal of Medicine that they have found a variant of the ASGR1 gene associated with reduced risk for CAD.