Genetics/Genomics News

Approximately 40% of cardiomyopathies are inherited, according to baseline data from the first European cardiomyopathy registry.

Patients who presented with early-onset CAD have a significant polygenic contribution that may be more common than familial hypercholesterolemia, according to a study published in Circulation: Genomic and Precision Medicine.

Preoperative peripheral blood mononuclear cell gene-expression profiles predicted early changes in organ function and long-term outcomes in patients with advanced HF who had a mechanical circulatory support device implanted, according to a study published in PLOS ONE.

The lifetime risk for atrial fibrillation is approximately 37% after age 55 years, greater than previous estimates, according to data published in Circulation.

An age, sex and gene expression score, or ASGES, can be used to assess older patients with symptoms of obstructive CAD, which may reduce the risk for procedure-related complications and unnecessary referrals, according to a study published in the Journal of the American Geriatrics Society.

Renova Therapeutics announced the FDA granted fast track status to its gene transfer treatment for patients with HF with reduced ejection fraction.

A Mendelian randomization study has identified that abnormal lipid levels, including LDL and HDL, appear to play an important role in the etiology of abdominal aortic aneurysms, and that lowering LDL may prevent development of or help manage AAA.

ANAHEIM, Calif. — Low levels of four specific metabolites were found to be associated with risk for incident CHD, according to new research from the BiomarCaRE consortium presented at the American Heart Association Scientific Sessions.

Drop in risk for CV events corresponded more closely with reduction in apolipoprotein B levels than with reduction in LDL levels, according to a Mendelian randomization study published in JAMA.

Children with homozygous familial hypercholesterolemia who were treated with rosuvastatin in addition to ezetimibe and/or apheresis reduced their LDL safely and effectively, according to a randomized, double blind crossover study published in the Journal of the American College of Cardiology.