Genetics/Genomics News

A genetic variant has been linked to hyperdynamic features associated with the early stages of hypertrophic cardiomyopathy, according to findings published in JAMA Cardiology.

A common genetic variant, chromosome 4q25 single nucleotide polymorphism, has been linked to increased risk for atrial fibrillation in the Hispanic/Latino population, according to new data published in PLOS ONE.

Newly identified genetic loci were associated with smoking status and BP regulation, according to a meta-analysis published in The American Journal of Human Genetics.

Physical activity and fitness were inversely associated with incident CVD among patients from the general population and those with an elevated genetic risk for CVD, according to a study published in Circulation.

In this Cardiology Today video exclusive, Sony Tuteja, PharmD, MS, research assistant professor of translational medicine and human genetics at Penn Medicine, and Jay S. Giri, MD, MPH, director of peripheral intervention and assistant professor of medicine at the Hospital of the University of Pennsylvania and a Cardiology Today Next Gen Innovator, discuss the results of the ADAPT trial.

In patients prescribed antiplatelet therapy after PCI, clopidogrel was less effective in those who had a CYP2C19 loss-of-function allele, according to the results of a single-center observational study.

ORLANDO, Fla. — In the ACCELERATE cohort, a pharmacogenetic analysis did not find that evacetrapib improved outcomes for patients with a certain genetic variant, according to findings presented at the American College of Cardiology Scientific Session.

ORLANDO, Fla. — Selection of antiplatelet therapy based on genetic information in addition to a patient’s clinical characteristics reduced ischemic and bleeding complications in patients with ACS, researchers reported at the American College of Cardiology Scientific Session.

ORLANDO, Fla. — Performing a genetic test for nonresponse to clopidogrel often influenced physician choice of antiplatelet prescription after PCI, according to new data from the ADAPT trial.

Elevated incidence of CHD attributable to smoking was less prominent in those with a genetic predisposition to CHD than in those without it, according to a study published in Circulation: Genomic and Precision Medicine.