Genetics/Genomics News

Researchers analyzed the causes of severe high BP in patients with African ancestry.

In a new study, rare variants of the gene ARMC5 showed an association with hypertension found only in black adults.

Patients of European ancestry with proportion spliced in truncating variants in the titin, or TTN, gene had an abnormal phenotype exemplified by lower left ventricular ejection fraction regardless of their cardiomyopathy status, according to a study published in Circulation.

Among patients with dilated cardiomyopathy on implantable cardioverter defibrillator or cardiac resynchronization defibrillator therapies, titin-truncating variants in the TTN gene were associated with elevated risk for ventricular tachycardia and other arrhythmias, researchers reported.

High plasma levels of lipoprotein(a) were associated observationally and causally with elevated risk for ischemic stroke, according to a genetic study published in the Journal of the American College of Cardiology.

Two genome-wide polygenic risk scores were able to predict prevalent CAD in patients, according to a study published in Circulation: Genomic and Precision Medicine.

MIAMI — Patients with monogenic familial hypercholesterolemia had a higher risk for CVD compared with those without the familial hypercholesterolemia-causing variant or patients with polygenic familial hypercholesterolemia, according to the third-place oral poster winner presentation at the National Lipid Association Scientific Sessions.

MIAMI — Utilization of risk factors including ethnicity, coronary artery calcium scores, lipoprotein(a) levels and family history should be used as a method of early screening and prevention in the population of South Asian adults living in the United States, Dinesh Kalra, MD, FACC, FSCCT, FSCMR, said during a presentation at the National Lipid Association Scientific Sessions.

MIAMI — Genetic testing can benefit health care providers who treat patients at lipid clinics, especially for the diagnosis of conditions such as familial hypercholesterolemia, according to a presentation at the National Lipid Association Scientific Sessions.

MIAMI — Adding four more genes to traditional genetic testing may identify more patients with familial hypercholesterolemia, which may be especially beneficial for black patients in whom traditional scoring criteria may not be sufficient, according to data from the second-place oral poster winner presented at the National Lipid Association Scientific Sessions.