Genetics/Genomics News

Researchers have developed an online calculator to assess 5-year risk for life-threatening arrhythmic events in patients with long QT syndrome.

Higher alcohol consumption predicted by genetics was associated with elevated risk for peripheral artery disease and stroke, according to a study published in Circulation: Genomic and Precision Medicine.

Three machine learning approaches outperformed the Dutch Lipid Score to diagnose patients with genetic mutations that cause familial hypercholesterolemia, according to a study published in the European Journal of Preventive Cardiology.

Taimur Sher, MBBS, MD a hematologist, internist and oncologist at the Mayo Clinic Cancer Center who leads the Multispecialty Amyloidosis Clinic at Mayo Clinic in Jacksonville, Florida, spoke with Healio about how to recognize and diagnose transthyretin amyloidosis, the newest FDA-approved treatments and the importance of genetic counseling in disease management.

Regardless of polygenic risk score for CAD, lifetime risk for CVD varies greatly depending on exposure to elevated LDL and systolic BP, according to research presented at the virtual American College of Cardiology Scientific Session.

While not meeting a performance goal, genetic screening of patients with ACS or stable CAD after PCI to guide antiplatelet therapy choice numerically reduced serious adverse CV events, according to the results of the TAILOR PCI trial.

CAD, despite the success of secondary prevention, is pandemic and the leading cause of death in high-, middle- and low-income countries throughout the world.

Researchers have found the first associations between BP during pregnancy and placental DNA methylation at genes linked to fetal development and CVD later in life.

Two polygenic risk scores, one for predicting CHD and one for predicting CAD, did not meaningfully improve risk prediction beyond conventional risk factors, according to findings published in JAMA.

Genetic determinants of LDL levels may increase the risk for CVD among patients with hypercholesterolemia, according to a study published in JAMA Cardiology.