Serum iron level may predict HF after STEMI
Click Here to Manage Email Alerts
Adults with HF after hospitalization for STEMI have lower serum iron levels compared with those without HF after STEMI, data from a retrospective case-control study show.
“Determining whether serum iron levels can predict HF after STEMI could improve early recognition and management,” Guoli Lin, MM, of the department of cardiology at the Affiliated Hospital of Putian University in Fujian, China, and colleagues wrote in Clinical Cardiology. “The incidence of HF after acute MI is increasing. Clinical observation found that the occurrence of HF was more than 24 hours after acute MI. Therefore, sensitive indicators are needed to assess risk factors for HF before onset.”
Image: Adobe Stock
Lin and colleagues analyzed data from 41 patients with new-onset HF after hospitalization for STEMI between December 2021 and May 2022 (80.5% men; mean age, 64 years), as well as 31 controls (70.9% men; mean age, 64 years). Researchers assessed serum iron levels along with other clinical characteristics.
Researchers observed significant differences in levels of serum iron, N-terminal pro‐B‐type natriuretic peptide levels, left atrial diameter and left ventricular ejection fraction. In binary logistic regression analyses, researchers found serum iron was an independent predictor of HF (OR = 0.804; 95% CI, 0.699-0.924), as was troponin I level (OR = 1.072; 95% CI, 1.011-1.137; P < .05 for both).
Receiver operating characteristic analysis showed that the area under the curve for serum iron was 0.808 (95% CI, 0.707-0.908; P < .01). The best cutoff value of serum iron was 11.87 mol/L, with a sensitivity of 87.1% and a specificity of 68.3%, according to researchers.
“Serum iron levels are a risk factor for HF after STEMI,” the researchers wrote. “Though the study is small, it could lead to further studies on the relationship between iron levels, cardiovascular events and decisions on management.”
Collapse
Read more about
Click Here to Manage Email Alerts