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Vitamin D levels predicted neurologic outcomes after sudden cardiac arrest

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Vitamin D deficiency increased the risk for poor neurologic outcomes after sudden cardiac arrest, according to new data reported at Acute Cardiovascular Care 2014.

Jin Wi, MD, from Severance Cardiovascular Hospital in Seoul, Korea, presented results from a prospective analysis of 53 patients (77% men; mean age, 57 years) who were resuscitated after sudden cardiac arrest. Wi and colleagues assessed neurologic outcome by Cerebral Performance Category score at 6 months after discharge; a score of 1 or 2 was defined as a good outcome and a score of 3, 4 or 5 defined as a bad outcome. The researchers also stratified patients by vitamin D level, with 25-(OH)D <10 ng/mL classified as deficient.

Overall, the mean vitamin D level was 10.3 ng/mL, and 59% of patients had vitamin D deficiency, Wi reported.

According to the researchers, vitamin D level was lower in patients with a poor neurologic outcome compared with those with a good neurological outcome (7.9 ng/mL vs. 12.4 ng/mL; P=.002).

In addition, compared with patients without vitamin D deficiency, vitamin D-deficient patients were more likely to have a poor neurologic outcome (65% vs. 23%; P=.003) and die before 6 months (29% vs. 0%; P=.007).

Vitamin D deficiency was the significant independent of predictor of poor neurologic outcome after sudden cardiac arrest with absence of bystander cardiopulmonary resuscitation, first monitored nonshockable rhythm and baseline renal dysfunction (OR=7.13; 95% CI, 1.54-32.99), according to multivariate logistic analysis.

“Vitamin D deficiency increased the risk of poor neurological outcome after sudden cardiac arrest by sevenfold,” Wi said in a press release. “The only factors that had a greater impact on poor neurological outcome were the absence of bystander CPR or having a first monitored heart rhythm that was nonshockable. Our findings suggest that vitamin D deficiency should be avoided, especially in people with a high risk of sudden cardiac arrest. A large randomized clinical trial is needed to find out whether supplements of vitamin D can protect high-risk groups from having a sudden cardiac arrest.”

For more information:
Wi J. Abstract #P383. Presented at: Acute Cardiovascular Care 2014; Oct. 18-20; Geneva.

Disclosure: Wi reports no relevant financial disclosures.