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STEMI-RADIAL: Radial approach enhanced outcomes in PCI
MIAMI — Results from the STEMI-RADIAL trial presented at TCT 2012 have shown that using the radial approach vs. the femoral approach for PCI decreased major bleeding, access site complications and improved overall clinical outcomes in patients with STEMI.
Ivo Bernat, MD, PhD, assistant professor of medicine at University Hospital Pilsen in the Czech Republic, and colleagues conducted a national, parallel group trial at four high-volume centers. They randomly assigned 707 patients who presented within 12 hours of STEMI symptom onset to primary PCI with radial (n=348) or femoral access (n=359) approach.
The primary endpoint of major bleeding or access site complications occurred in 7.2% of the femoral access vs. 1.4% of the radial access group (P=.0001). At 30 days, the rate of major adverse CV events, defined as a composite of death, reinfarction and stroke, was 4.2% in the femoral access group and 3.5% in the radial access group (P=.7), according to a press release.
“In patients with STEMI undergoing PCI within 12 hours, the radial approach was associated with significantly lower incidence of major bleeding and access site complications, resulting in a significantly better net clinical benefit,” Bernat said in the release. “Moreover, the radial approach reduced significantly ICU stays and contrast volume compared to the femoral approach. Results of this trial support the use of the radial approach in primary PCI in high-volume centers as a first choice.”
For more information:
Bernat I. Plenary session XXVI. Late breaking clinical trials III. Presented at: TCT 2012; Oct. 22-26, 2012; Miami.
Disclosure: The trial was supported by the Charles University Research Fund and project of the Ministry of Health, Czech Republic, for development of University Hospital Pilsen. Bernat reports no relevant financial disclosures.