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Modifiable risk factors predictive of men and women at risk for HF
Goyal A. Circ Heart Fail. 2010;doi:10.1161/circheartfailure.110.938175.
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New data from a study that included more than 1 million person-years of follow-up has suggested that common, modifiable risk factors may accurately discriminate men and women at risk for HF.
Researchers examined the incidence and predictors of new HF diagnosed in outpatient or inpatient settings among men and women (n=359,947) who were insured by Kaiser Permanente Georgia from 2000 to 2005. Patients were free of HF at baseline, and study investigators developed multivariable Cox models to determine the association between incident HF and antecedent factors, including CHD, hypertension, diabetes mellitus, atrial fibrillation and valvular heart disease.
During the 1,015,794 person-years follow-up, there were 4,001 incident HF cases (48% in patients older than 65 years), with a greater incidence rate in men than women (4.24 vs. 3.68 per 1,000 person years).
According to researchers, two-thirds of incident HF cases occurred in outpatients, with the antecedent factors and age yielding what they termed as “excellent discrimination for incident HF in both outpatients and inpatients, and in both sexes.”
Regarding their main conclusions, the researchers wrote, “Common, modifiable risk factors accurately discriminate women and men at risk for HF diagnosed in either outpatient or inpatient settings. Approximately two-thirds of new HF cases in our insured population were diagnosed in outpatients. More research is needed to characterize these subjects and their prognosis.”
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