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Gender discrepancies observed in CAD detected by CTA
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SCCT 6th Annual Meeting
DENVER — According to data presented at the Scientific Meeting of the Society of Cardiovascular Computed Tomography, the prevalence of coronary artery disease as evaluated by CTA was significantly higher in men compared with women, despite men being significantly younger than women in the study population.
This difference in severity could be slightly related to the study population “because it was a cohort study,” Andrea L. Vavere, PhD, trial researcher with Johns Hopkins University, said in an interview. “If it was a population-based study, we’d expect the findings to be different.”
In the study, Vavere and colleagues from Johns Hopkins and institutions around the world looked at 291 participants (26.5% women) from the CorE64 trial, which tested 64-detector CTA against invasive coronary angiography. A modified Duke CAD index was used to determine clinically significant CAD (>50% stenosis).
According to data, the mean age for men in the study was 59.7 years vs. 63.5 years for women (P=.0007). Conversely, CAD was significantly higher in men (68% vs. 49%; P=.001). Among men, the mean CTA CAD severity score was 22.92 vs. 24.3 for invasive coronary angiography, whereas the scores were 15.5 vs. 14.4 in women.
After adjustment for CV risk factors, a significant difference was still found in mean CTA CAD severity for males compared with females.
The implications for clinical practice, Vavere said, is that “disease burden may be different between the genders and you’re able to identify that burden with CT similarly as cath.” – by Brian Ellis
For more information:
- Vavere A. Abstract #176. Presented at: The 6th Annual Scientific Meeting of the Society of Cardiovascular Computed Tomography; July 14-17, 2011; Denver.
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