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CREST

Carotid Revascularization Endarterectomy Versus Stenting

Issue: April 2010

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Trial compared carotid artery stenting with carotid endarterectomy for the prevention of stroke in patients with symptomatic or asymptomatic extracranial carotid stenosis.

Design: prospective, randomized
Patients: 2,502
Centers: 117
Country: United States

RESULTS: During the 30-day period following the procedures, stroke rate was 2.3% in patients undergoing surgery vs. 4.1% in patients undergoing stenting (HR=1.79; 95% CI, 1.14-2.82). Rates of MI were higher in patients undergoing surgery vs. those undergoing stenting (2.3% vs. 1.1%; HR=0.50; 95% CI, 0.26-0.94). Patients aged younger than 69 years tended to have better outcomes than older patients, including a larger stent benefit as the age of the patient decreased. In patients aged older than 70 years, results of endarterectomy were better than stenting results, with larger benefits for surgery as the age of the patient increased.

Presented at ISC 2010.

Click here to read more about the CREST trial.