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ASTRAL
Angioplasty and Stenting for Renal Artery Lesions
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Trial evaluated efficacy of renal artery stenting with medical therapy vs. medical therapy alone for improvement of renal function.
Design: randomized, unblended
Patients: 806
Centers: 57
Countries: United Kingdom, Australia,
New Zealand
RESULTS: The overall mean slope of the reciprocal of the serum creatinine concentration was –0.07×10–3 L/mcmol per year in the revascularization group vs. –0.13×10–3 L/mcmol per year in the medical therapy alone group (P=.06). The mean reciprocal of the creatinine level during the five years of follow-up was 0.09×10-3 L/mcmol higher in the revascularization group vs. the medical therapy group (95% CI, –0.02 to 0.20; P=.10). Revascularization was attempted in 335 of the 403 patients (83%) and was deemed a technical success in 317 of the 335 patients (95%). No significant differences between study groups for renal and CV events or for mortality were reported.
Published in: N Engl J Med. 2009;361:1953-1962.
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