Thyroid Eye Disease: Navigating Orbital Pathways to New Treatment Options – A GameOn! Challenge

Overview

Provider Statement

This continuing medical education activity is provided by

Support Statement

This activity is supported by an educational grant from Horizon Therapeutics USA, Inc.

Activity Description

Thyroid eye disease (TED) is an autoimmune disorder believed to result from the stimulation of several receptors located in the orbital fibroblasts. It is frequently misdiagnosed, due to both its heterogeneous clinical presentation and a failure on the part of clinicians to understand the relationship between TED and hyperthyroidism. Misdiagnosis can place patients at risk, as management of TED is most effective during the initial, active phase of the disease. However, differential diagnosis can be achieved with the assistance of imaging, and early treatment may limit disfigurement and reduce vision loss. Ophthalmologists should be knowledgeable about the presentation of these patients, which includes patients with dry eye, as well as conventional and new treatment options available for the treatment of patients with TED. In this case-based program, expert faculty discuss these treatment options, including teprotumumab—the first and only medical agent approved by the US Food and Drug Administration for the treatment of TED. This program includes the unique, audience-engaging, educational gaming platform, A GameOn! Challenge.

Target Audience

The intended audience for this activity is ophthalmologists and other health care professionals involved in the management of patients with thyroid eye disease.

Learning Objectives

Upon successful completion of this activity, participants should be better able to:

• Assess the pathogenesis of TED, including targets for treatment.
• Review the clinical presentation of TED, its symptomatology, and optimal methods to differentially diagnose the condition to aid in early detection and treatment.
• Examine currently available TED treatments for their efficacy, safety, and ability to restore visual function and appearance.

Activity Chair

Raymond S. Douglas, MD, PhD
Professor of Surgery
Division of Ophthalmology
Director, Orbital and Thyroid Eye Disease Program
Cedars-Sinai Medical Center
Los Angeles, CA

Faculty

Andrea Lora Kossler, MD, FACS
Director, Oculofacial Plastic and Orbital Surgery
Associate Professor of Ophthalmology
Byers Eye Institute at Stanford University School of Medicine
Palo Alto, CA

Jennifer M. Loh, MD
Founder, Loh Ophthalmology Associates
Board Member, Eye Physicians of Florida, LLP
Miami, FL

Prem S. Subramanian, MD, PhD
Professor of Ophthalmology, Neurology, and Neurosurgery
University of Colorado School of Medicine
Vice Chair for Academic Affairs
Division Head, Neuro-Ophthalmology
University of Colorado Sue Anschutz-Rodgers Eye Center
Aurora, CO

Reviewer

Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP

Accreditation

Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation

Vindico Medical Education designates this enduring material for a maximum of 1.25 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This enduring material is approved for 1 year from the date of original release, November 17, 2022, to November 16, 2023.

How to Participate in This Activity and Obtain CME Credit

To participate in this CME activity, you must read the objectives, answer the polling and pretest questions, view the content, and complete the posttest and evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering 3 of the 4 posttest questions correctly. Upon receipt of the completed materials, if a satisfactory score on the posttest is achieved, Vindico Medical Education will issue an AMA PRA Category 1 Credit(s)™ certificate.

Disclosures

Vindico Medical Education adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a continuing education activity, including faculty, planners, reviewers, or others, are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Activity Chair and Faculty report the following relevant financial relationship(s)

Raymond S. Douglas, MD, PhD
Employee: RVL Pharmaceuticals*
Consultant: Horizon, Valencia Bio Pharma, Vasaragen, Viridian

Andrea Lora Kossler, MD, FACS
Consultant: Horizon, Immunovant
Independent Research Contractor: Horizon, Sling Shot Therapeutics, Viridian

Jennifer M. Loh, MD
Consultant: Horizon, Novartis

Prem S. Subramanian, MD, PhD
Consultant: Horizon, Viridian
Independent Research Contractor: Horizon, Viridian

Reviewer reports the following relevant financial relationship(s)

Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP
No relevant financial relationships to disclose.

Vindico Medical Education staff report the following relevant financial relationship(s)

No relevant financial relationships to disclose.

Signed disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.

*The contents of this activity are not related to the business lines or products of the employer.

Unlabeled and Investigational Usage

The audience is advised that this continuing medical education activity may contain references to unlabeled uses of US Food and Drug Administration (FDA)–approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage. All activity participants will be informed if any speakers/authors intend to discuss either non–FDA-approved or investigational use of products/devices.

Copyright Statement

Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680. Printed in the USA. © 2022 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. The material presented at or in any of Vindico Medical Education continuing medical education activities does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the US Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or utilizing any product.

CME Questions?

Contact us at cme@vindicoCME.com