Best Practices in the Diagnosis and Management of Homozygous Familial Hypercholesterolemia: Towards Individualized Treatment Strategies

Overview

Release Date: November 9, 2023
Expiration Date: (12 months after release date): November 9, 2024

Program Description

This roundtable discussion with expert faculty will provide learners with the latest advances in diagnosing and managing patients with Homozygous Familial Hypercholesterolemia (HoFH). The goal of the activity is for learners to be better able to recognize the signs and symptoms of HoFH, the diagnostic criteria for this disease, the recommendations for cascade screening, as well as current strategies for individualizing treatment of HoFH in children and adults, including a review of angiopoietin-like 3 (ANGPTL3) inhibitors and it’s role in the management of HoFH.

Intended Audience

This activity is intended for cardiologists, lipidologists, endocrinologists, internists, infusion center nurses, pediatricians, and other healthcare providers involved in the care of patients with FH, including HoFH.

Commercial Supporter

This activity is supported by an independent medical educational grant from Regeneron Pharmaceuticals, Inc.

Educational Objectives

Upon completion of the educational activity, participants should be able to:

1.Implement strategies for the timely diagnosis of HoFH
2. Discuss the role of cascade screening in identifying patients with HoFH
3. Integrate current approved therapies for the treatment of HoFH
4. Individualize treatment for patients with HoFH based on response to therapy and/or disease genetics

Physician Continuing Education

In support of improving patient care, this activity has been planned and implemented by Horizon CME. Horizon CME is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Designation Statement

Horizon CME designates this enduring activity for a maximum of 1.0 AMA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the enduring activity.

Conflicts of Interest Disclosure Policy

In accordance with the ACCME Standards for Commercial Support, Horizon CME must ensure balance, independence, objectivity, and scientific rigor. Prior to an activity, all faculty, authors, editors, and planning committee members participating in a Horizon CME activity are required to disclose to attendees any relevant financial interest or other relationships with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services that are discussed in an educational activity. Horizon CME has mitigated any conflicts of interest for this activity.

Disclosure of Unlabeled Use

Horizon CME requires that faculty participating in any continuing medical education (CME) to disclose to the audience when discussing any unlabeled or investigational use of any commercial product or device not yet approved for use in the United States.

Disclaimer

This activity is designed for educational purposes. Participants have a responsibility to utilize this information to enhance their professional development to improve patient outcomes. Conclusions drawn by the participants should be derived from careful consideration of all available scientific information. The participant should use his/her clinical judgment, knowledge, experience, and diagnostic decision-making before applying any information, whether provided here or by others, for any professional use.

Moderator

James A. Underberg, MD, MS, FACP, FNLA
Clinical Assistant Professor of Medicine
NYU Center for Prevention of Cardiovascular Disease
NYU School of Medicine
New York, NY

Dr. Underberg is a Clinical Lipidologist. He is a Clinical Assistant Professor of Medicine at NYU School of Medicine and the NYU Center for Prevention of Cardiovascular Disease. His Undergraduate and Graduate degrees are from Yale University and his medical degree is from the University of Pennsylvania. His internship and residency was at NYU and Bellevue Hospitals in NYC. Dr. Underberg is the Director of the Bellevue Hospital Lipid Clinic. He holds joint appointments in the divisions of General Internal Medicine and Endocrinology at NYU.

Dr. Underberg is Master of the National Lipid Association, Past-President of the National Lipid Association, Past-President of the American Board of Clinical Lipidology & Current President of the Foundation of the National Lipid Association. He serves on the editorial board of the Journal of Clinical Lipidology and is a Section editor of Current Atherosclerosis Reports.

Dr. Underberg’s Clinical Interests focus on the clinical management of patients with lipids and lipoprotein disorders and cardiovascular disease prevention. He maintains an active clinical research program in these areas and has authored numerous articles and book chapters in the field of Clinical Lipidology.

He sees patients both at Bellevue Hospital and in a private practice setting.

Faculty

Julie Brothers, MD, FAAP
Medical Director, Lipid Heart Clinic
Co-Medical Director, Preventive Cardiovascular Program
Medical Director, Coronary Anomaly Management Program
Associate Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Philadelphia, PA

Julie Brothers, MD is the Medical Co-Director of the Preventive Cardiovascular Program and the Medical Director of the Lipid Heart Clinic at the Children’s Hospital of Philadelphia, a position she has held for over 15 years. She has served as Principal Investigator on several clinical trials in the pediatric dyslipidemia population and has published many manuscripts and book chapters on this topic. She is committed to promoting a heart healthy lifestyle in all children with lipid disorders.

Seth S. Martin, MD, MHS
Director of the Advanced Lipid Disorders Program and Digital Health Lab
Ciccarone Center for the Prevention of Cardiovascular Disease
Associate Professor of Medicine
Johns Hopkins University School of Medicine
Baltimore, MD

Seth S. Martin, MD, MHS, FACC, FAHA, FASPC is a Professor of Medicine, Cardiologist, and Lipid Specialist at the Johns Hopkins University School of Medicine. He is a core faculty member in the Ciccarone Center for the Prevention of Cardiovascular Disease and Director of the Advanced Lipid Disorders Center. Dr. Martin is the Faculty leader for the Barker Firm of the Osler Medical Residency. He has a longstanding passion for preventive cardiology and lipidology. He is committed to patient-centered care and is a member of the Johns Hopkins bedside medicine faculty. Dr. Martin has published more than 300 articles in leading cardiology and medicine journals, more than 20 book chapters, and served as the editor for the book Precision Medicine in Cardiovascular Disease Prevention. He is an associate editor for the Journal of Clinical Lipidology and European Journal of Preventive Cardiology, and is on the Editorial Board of the American Journal of Preventive Cardiology. Dr. Martin was selected as one of 125 individuals who personify Johns Hopkins Medicine’s mission to improve the health of the community and the world by setting the standard of excellence in medical education, research and clinical care, in celebration of the Johns Hopkins University School of Medicine’s 125th anniversary.

Faculty Disclosures

Julie Brothers, MD, FAAP, has served on an advisory board for Regeneron Pharmaceuticals.

Seth S. Martin, MD, MHS, FACC, FAHA, FASPC, has served on an advisory board and a consultant for Amgen, AstraZeneca, New Amsterdam, and Novartis as well as conducted research for Amgen and Merck.

James A. Underberg, MD, MS, FACP, FNLA, has served on a speakers bureau for Amarin, Amgen, Amryt and Regeneron as well as on an advisory board for Esperion, Merck, Novartis, Pfizer, and Precision Bio. He is also a consultant for Amgen and conduct research for Amryt.

Instructions to Recieve Credit

There are no fees for participating and receiving CME credit for this enduring activity. To receive CME credit participants must:

1. Read the CME/CE information and faculty disclosures.
2. Participate in the online activity.
3. Complete the post-test.
4. Complete the evaluation form available. The last day to access the evaluation is November 9, 2024 at 11:59pm PST (Pacific Standard Time)

For CME questions please contact: admin@horizoncme.com

To receive CME/CE credits, participants must complete the pre and post assessment questions and the program evaluation. Certificates will be distributed online at the conclusion of the activity. Your online certificate will be saved within your Dashboard or Transcript, which you can access at any time. For information about the accreditation of this program, please contact: admin@horizoncme.com.