Differential Diagnosis
Differentiating Factors
Cutaneous Dermatomyositis (DM) manifestations can sometimes overlap with those of other connective tissue diseases, resulting in misdiagnosis of lupus erythematosus (LE) due to photodistributed cutaneous lesions that have histologic features similar to DM upon biopsy.
Other conditions can also present with muscle weakness and should be excluded by history, physical exam, and differentiating factors (Table 2-4). Awareness of characteristic cutaneous and muscular signs can help diagnose DM in these patients.
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Differentiating Factors
Cutaneous Dermatomyositis (DM) manifestations can sometimes overlap with those of other connective tissue diseases, resulting in misdiagnosis of lupus erythematosus (LE) due to photodistributed cutaneous lesions that have histologic features similar to DM upon biopsy.
Other conditions can also present with muscle weakness and should be excluded by history, physical exam, and differentiating factors (Table 2-4). Awareness of characteristic cutaneous and muscular signs can help diagnose DM in these patients.
References
- Aggarwal, R., Schessl, J., Charles-Schoeman, C. et al. Safety and tolerability of intravenous immunoglobulin in patients with active dermatomyositis: results from the randomised, placebo-controlled ProDERM study. Arthritis Res Ther 26, 27 (2024).
- ArgenX Press Release. Argenx Advances Clinical Development of Efgartigimod SC in Idiopathic Inflammatory Myopathies. November 20, 2024. https://argenx.com/content/dam/argenx-corp/newsroom/press-release-pdfs/PressRelease_argenx_ALKIVIA_Ph2_20241120.pdf.coredownload.inline.pdf
