Clinical Trials
GLORIA-AF
The Global Registry on Long-Term Oral Anti-Thrombotic Treatment in Patients with Atrial Fibrillation compared the use of non-vitamin K oral anticoagulants with warfarin in patients with nonvalvular AF over time.
Purpose: Comparison of non-vitamin K oral anticoagulants vs. warfarin in patients with nonvalvular atrial fibrillation
Design: Prospective, registry
Treatment Group: Non-vitamin K anticoagulants
Control Group: Warfarin
Patients: 15,092
Centers: 544
Countries: 21
Results: Among the cohort, for stroke prevention, 79.9% received oral anticoagulation (non-vitamin K oral anticoagulants, 47.6%; warfarin, 32.3%), 12.1% received antiplatelet agents and 7.8% received no antithrombotic treatment. In North America, 52.1% of patients received non-vitamin K oral anticoagulants, 26.2% received warfarin, 14% received antiplatelet agents and 7.5% received no antithrombotic treatment. In Europe, the rate of adoption of non-vitamin K oral anticoagulants was similar (52.3%). In Asia, it was less (27.7%).
Original Publications:
Huisman MV, et al. J Am Coll Cardiol. 2017;doi:10.1016/j.jacc.2016.11.061.
Healio/Cardiology News Coverage:
Oral anticoagulants underused for stroke prevention in patients with nonvalvular AF