Clinical Trials
COMMIT
Trial Details:
Acronym: ClOpidogrel and Metoprolol in Myocardial Infarction Trial
Purpose: To evaluate the addition of metoprolol (beta-blocker) OR clopidogrel in acute coronary syndromes
Format: Double blind, multicenter, randomized control trial
Treatment Group: Metoprolol and/or clopidogrel
Control Group: Placebo
Number of Patients: 45,852
Follow-up: 28 days
Inclusion Criteria: ST elevation, left bundle branch block (LBBB) or ST depression on ECG within 24 hours of suspected symptoms of acute coronary syndrome
Exclusion Criteria:
- Patients undergoing PCI (since clopidogrel would have to be used in this group)
- Serious illness (i.e. metastatic cancer)
- Systolic blood pressure < 100 mmHg or heart rate < 50 BPM
Primary Endpoints:
- Composite of death, reinfarction, or cardiac arrest
- Death from any cause
Secondary Endpoint:
- Reinfarction
- Ventricular fibrilation
- Cardiac arrest
- Cardiogenic shock
Summary:
The addition of clopidogrel to aspirin during acute coronary syndromes reduced death, stroke and reinfarction. There was no difference in major bleeding.
Beta-blocker versus placebo as initial therapy in acute coronary syndromes. There was no difference in the composite endpoint of death, infarction and cardiac arrest. Beta-blockers decreased in reinfarction and ventricular fibrillation arrest. Beta-blockers increased risk of cardiogenic shock.
Original Publications:
Chen ZM, et al. Lancet. 2005;doi:10.1016/S0140-6736(05)67660-X
Chen ZM, et al. Lancet. 2005;doi:10.1016/S0140-6736(05)67661-1