Alfieri stitch and mitral clip: The Alfieri stitch is a surgical technique during which a suture was placed between the A2 and P2 segments of the mitral valve. This resulted in two mitral valve orifices. It was shown to significantly reduce the degree of mitral regurgitation, but may result in some degree of mitral stenosis. This is best suited for functional mitral regurgitation from annular dilation. Inserting a clip percutaneously between the A2 and P2 mitral valve leaflet segments has been done successfully, although research to support its use is lacking.

Coronary sinus: A percutaneous procedure has been developed during which a ring is placed in the coronary sinus (which runs along the external part of the mitral annulus) and the ring is tightened to allow the mitral valve leaflets to coapt better in systole.