The two therapies that have been researched to reduce myalgias in patients taking statin therapy (HMG CoA reductase inhibitors) are coenzyme Q10 and vitamin D.

Two very small trials of coenzyme Q10 were conflicting as to the efficacy of this therapy to relieve statin induced myalgias. Likewise, some studies, but not all, have shown that replacing vitamin D in patients who are deficient can relieve similar myalgias. 

Better strategies include switching therapy to statins with less intrinsic muscle toxicity (fluvastatin and pravastatin) or alternate day dosing. Some have even had success with once weekly dosing of rosuvastatin.