Tanios Bekaii-Saab, MD

William I. Wolff, MD, who will be remembered in the history of modern medicine as the co-developer of colonoscopy, died at age 94 in late August. Back in the 1960s, Dr. Wolff was working with Hiromi Shinya, MD, to probe the full length of the colon using a tube with electronic sensors. Their most significant advance was a device designed by Shinya in collaboration with Olympus Optical Company — a wire loop snare-cautery that enabled physicians to remove a polyp immediately, making a second procedure unnecessary.

At ASCO 2011, during a presentation from Sabine Tejpar, MD, PhD, data from a retrospective analysis that she presented suggested a heterogeneous treatment effect from cetuximab according to KRAS mutation status.