Most recent by Marquetta Flaugher, PhD, ARNP
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April 15, 2015
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Anemia associated with Alinia monotherapy when used longer than FDA-approved duration
Alinia, the first thiazolide, was approved in 2002 by the FDA for the treatment of protozoal and helminthic infections. It was hypothesized that the drug may have possible antiviral activity by increasing the phosphorylation of double-stranded RNA-dependent protein kinase and the induction of eukaryotic-initiation of factor 2-alpha, which is an important factor in the innate immune response against hepatitis C infection.