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At Issue: Stem cell therapy

Articular cartilage stands to benefit the most from stem cell therapy. While stem cells have been identified in nearly every human tissue, articular cartilage contains few regenerative cells. Cartilage is avascular and is devoid of a perivascular (pericyte) stem cell population, so when injury occurs, there is little response from the cartilage tissue itself. Migrating synovial cells may contribute to the body’s often-inadequate healing response.