Amit G. Singal, MD, MS

This month’s cover story highlights the growing burden of hepatocellular carcinoma, the most common type of primary liver cancer, in the United States. Despite being a cancer that does not typically receive much attention, HCC is projected to become the third leading cause of cancer-related death in the United States by 2040 if current trends continue. Its increasing mortality is related to a growing number of cases in the setting of non-alcoholic fatty liver disease, the liver manifestation of the metabolic syndrome, and a high proportion of HCC cases being detected at a late stage. While patients detected at an early stage are amenable to curative therapies such as liver transplantation and have a median survival exceeding 5 years, those diagnosed at a late stage traditionally have had limited therapeutic options and a median survival of only 1 year.